Mary O’Connor majored in biochemistry at Yale and earned her M.D. in 1985 from the Medical College of Pennsylvania. She completed her residency in orthopedics at the Mayo Clinic in Rochester, MN in 1990 and her fellowship in orthopedic oncology there in 1991. She practiced at Mayo Clinic in Florida until 2015, when she became the inaugural Director of The Center for Musculoskeletal Care at Yale-New Haven, leading the creation of a new value and patient focused model of care delivery in an academic medical setting, bringing together specialists in orthopaedics, neurosurgery, neurology, rheumatology, rehabilitation, biomedical engineering to provide a wide range of services, including joint replacement, pain management, and advanced treatment for arthritis, spine disorders, multiple sclerosis, Parkinson disease, among others. She is Chair of the Diversity Advisory Board of the American Academy of Orthopaedic Surgeons.

member of the Musculoskeletal Tumor Society (MSTS), the American Association of Hip and Knee Surgeons (AAHKS) and The Knee Society. She is the Past President of the Association of Bone and Joint Surgeon, AAHKS, MSTS and the Ruth Jackson Orthopaedic Society. She is a member of the Perry Foundation Board, past member of the Advisory Committee on Research on Women’s Health at the National Institutes of Health and past Chair of the American Academy of Orthopaedic Surgeons Women’s Health Issues Advisory Board. She has served as the Co-Chair of the Movement is Life Caucus since its founding in 2010.

Mary has received numerous awards and honors, including being named a Distinguished Clinician at Mayo Clinic and receiving The Corinne Farrell Award from the International Skeletal Society in 2009. She received the Congressional Gold Medal as a 1980 Olympian in crew and is noted for her encouragement of women in career advancement.

Mary is a former H.D. and currently serves as a co-chair of the Annual Fund and as a mentor in the SAMI program.